Drug interactions
Elbasvir / grazoprevir + Posaconazole
Severity: Major
Elbasvir / grazoprevir and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole may increase elbasvir and grazoprevir concentrations, which depend on CYP3A4 for metabolism. Increased grazoprevir exposure is linked to ALT elevations and hepatotoxicity.
What this interaction means in plain words
Elbasvir / grazoprevir and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
CYP3A4 inhibition by posaconazole decreases clearance of elbasvir and grazoprevir.
What to do
Avoid the combination if possible. If used, monitor liver enzymes closely and consider an alternative antifungal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Elbasvir / grazoprevir with Posaconazole?
MediHelp rates the interaction as major. Elbasvir / grazoprevir and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole may increase elbasvir and grazoprevir concentrations, which depend on CYP3A4 for metabolism. Increased grazoprevir exposure is linked to ALT elevations and hepatotoxicity.
How serious is the interaction between Elbasvir / grazoprevir and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible. If used, monitor liver enzymes closely and consider an alternative antifungal.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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