Drug interactions
Eletriptan + Istradefylline
Severity: Moderate
Eletriptan and Istradefylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
At higher doses, istradefylline inhibits CYP3A4 and P-glycoprotein and may raise eletriptan exposure. The effect is less likely at lower doses.
What this interaction means in plain words
Eletriptan and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Istradefylline belongs to Central Nervous System.
Why it happens
Dose-dependent inhibition of CYP3A4 and P-glycoprotein by istradefylline.
What to do
Monitor for increased triptan adverse effects, particularly with istradefylline 40 mg daily. Consider a lower eletriptan dose or an alternative triptan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Istradefylline
Frequently asked questions
Can I take Eletriptan with Istradefylline?
MediHelp rates the interaction as moderate. Eletriptan and Istradefylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. At higher doses, istradefylline inhibits CYP3A4 and P-glycoprotein and may raise eletriptan exposure. The effect is less likely at lower doses.
How serious is the interaction between Eletriptan and Istradefylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased triptan adverse effects, particularly with istradefylline 40 mg daily. Consider a lower eletriptan dose or an alternative triptan.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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