Drug interactions
Eletriptan + Miconazole
Severity: Moderate
Eletriptan and Miconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eletriptan is extensively metabolized by CYP3A4, and strong inhibitors markedly increase its exposure. Miconazole is a CYP3A4 inhibitor, but vaginal use gives limited systemic levels. Higher eletriptan levels could increase vasoconstrictive and cardiovascular effects.
What this interaction means in plain words
Eletriptan and Miconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Miconazole belongs to Anti Fungals.
Why it happens
Miconazole inhibits CYP3A4, reducing first-pass and systemic metabolism of eletriptan.
What to do
Monitor for increased adverse effects such as nausea, chest tightness and blood pressure rise. Avoid eletriptan within several days of systemic miconazole; with vaginal use, use the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Miconazole
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Miconazole?
MediHelp rates the interaction as moderate. Eletriptan and Miconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eletriptan is extensively metabolized by CYP3A4, and strong inhibitors markedly increase its exposure. Miconazole is a CYP3A4 inhibitor, but vaginal use gives limited systemic levels. Higher eletriptan levels could increase vasoconstrictive and cardiovascular effects.
How serious is the interaction between Eletriptan and Miconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased adverse effects such as nausea, chest tightness and blood pressure rise. Avoid eletriptan within several days of systemic miconazole; with vaginal use, use the lowest effective dose.
What other medicines interact with Miconazole?
MediHelp also lists interactions of Miconazole with, for example, Cabazitaxel, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Miconazole page.
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