Drug interactions
Eletriptan + Morphine
Severity: Minor
Eletriptan and Morphine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of an opioid and a triptan has been associated with serotonin syndrome in rare reports. The risk with morphine is considered low compared with more serotonergic opioids.
What this interaction means in plain words
Eletriptan and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eletriptan belongs to Central Nervous System; Morphine belongs to Musculoskeletal.
Why it happens
Possible additive serotonergic activity; the mechanism for morphine is weak and not firmly established.
What to do
Co-administration is generally acceptable; counsel patients to report agitation, tremor, sweating or fever. Avoid frequent use of both for headache because of medication-overuse headache.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Morphine
- Alvimopan + Morphine Contraindicated
- Isocarboxazid + Morphine Contraindicated
- Morphine + Olanzapine / samidorphan Contraindicated
- Morphine + Phenelzine Contraindicated
- Morphine + Tranylcypromine Contraindicated
- Alfentanil + Morphine Major
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Morphine?
MediHelp rates the interaction as minor. Eletriptan and Morphine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Concurrent use of an opioid and a triptan has been associated with serotonin syndrome in rare reports. The risk with morphine is considered low compared with more serotonergic opioids.
How serious is the interaction between Eletriptan and Morphine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Co-administration is generally acceptable; counsel patients to report agitation, tremor, sweating or fever. Avoid frequent use of both for headache because of medication-overuse headache.
What other medicines interact with Morphine?
MediHelp also lists interactions of Morphine with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Morphine page.
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