Drug interactions
Eletriptan + Nifedipine
Severity: Minor
Eletriptan and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine is only a weak CYP3A4 inhibitor, so a meaningful rise in eletriptan levels is unlikely. Eletriptan can cause a small rise in blood pressure, which may be relevant in hypertensive patients.
What this interaction means in plain words
Eletriptan and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eletriptan belongs to Central Nervous System; Nifedipine belongs to Cardiovascular.
Why it happens
Weak CYP3A4 inhibition by nifedipine may marginally reduce eletriptan metabolism.
What to do
No dose change is needed; monitor blood pressure and triptan adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Nifedipine
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Nifedipine?
MediHelp rates the interaction as minor. Eletriptan and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine is only a weak CYP3A4 inhibitor, so a meaningful rise in eletriptan levels is unlikely. Eletriptan can cause a small rise in blood pressure, which may be relevant in hypertensive patients.
How serious is the interaction between Eletriptan and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor blood pressure and triptan adverse effects.
What other medicines interact with Nifedipine?
MediHelp also lists interactions of Nifedipine with, for example, Amifostine, Amlodipine-benazepril, Apalutamide. The full list is on the Nifedipine page.
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