Drug interactions
Eletriptan + Palonosetron
Severity: Moderate
Eletriptan and Palonosetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Serotonin syndrome has been rarely reported with 5-HT3 antagonists and triptans together. The risk is low but clinicians should be aware.
What this interaction means in plain words
Eletriptan and Palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Palonosetron belongs to Gastrointestinal Tract.
Why it happens
Possible additive serotonergic effects; not firmly established.
What to do
Co-use is acceptable when needed; counsel on serotonin syndrome symptoms and monitor. Stop both and give supportive care if it develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Palonosetron
- Apomorphine + Palonosetron Contraindicated
- Isocarboxazid + Palonosetron Major
- Palonosetron + Phenelzine Major
- Palonosetron + Tranylcypromine Major
- Almotriptan + Palonosetron Moderate
- Amitriptyline + Palonosetron Moderate
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Palonosetron?
MediHelp rates the interaction as moderate. Eletriptan and Palonosetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Serotonin syndrome has been rarely reported with 5-HT3 antagonists and triptans together. The risk is low but clinicians should be aware.
How serious is the interaction between Eletriptan and Palonosetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Co-use is acceptable when needed; counsel on serotonin syndrome symptoms and monitor. Stop both and give supportive care if it develops.
What other medicines interact with Palonosetron?
MediHelp also lists interactions of Palonosetron with, for example, Apomorphine, Isocarboxazid, Phenelzine. The full list is on the Palonosetron page.
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