Drug interactions
Eletriptan + Rasagiline
Severity: Moderate
Eletriptan and Rasagiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents have serotonergic activity, so combined use raises a theoretical risk of serotonin syndrome. Eletriptan is mainly metabolized by CYP3A4 rather than MAO, so exposure is not expected to rise markedly.
What this interaction means in plain words
Eletriptan and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Why it happens
Additive serotonergic effects; rasagiline's MAO-B selectivity limits pharmacokinetic effects.
What to do
Monitor for signs of serotonin toxicity when used together and use the lowest effective triptan dose. Consider an alternative migraine therapy if symptoms arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Rasagiline?
MediHelp rates the interaction as moderate. Eletriptan and Rasagiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents have serotonergic activity, so combined use raises a theoretical risk of serotonin syndrome. Eletriptan is mainly metabolized by CYP3A4 rather than MAO, so exposure is not expected to rise markedly.
How serious is the interaction between Eletriptan and Rasagiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of serotonin toxicity when used together and use the lowest effective triptan dose. Consider an alternative migraine therapy if symptoms arise.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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