Drug interactions
Eletriptan + Rufinamide
Severity: Minor
Eletriptan and Rufinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rufinamide is a weak CYP3A4 inducer and could slightly reduce eletriptan exposure. The clinical effect is likely small but could reduce migraine relief in some patients.
What this interaction means in plain words
Eletriptan and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eletriptan belongs to Central Nervous System; Rufinamide belongs to Central Nervous System.
Why it happens
Weak induction of CYP3A4 by rufinamide may increase eletriptan clearance.
What to do
No routine adjustment is needed. Reassess triptan efficacy if migraine response appears reduced after rufinamide is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Rufinamide
- Carbamazepine + Rufinamide Moderate
- Desogestrel-ethinyl estradiol + Rufinamide Moderate
- Dronedarone + Rufinamide Moderate
- Esketamine + Rufinamide Moderate
- Ethinyl estradiol-drospirenone + Rufinamide Moderate
- Ethinyl estradiol-levonorgestrel + Rufinamide Moderate
Frequently asked questions
Can I take Eletriptan with Rufinamide?
MediHelp rates the interaction as minor. Eletriptan and Rufinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rufinamide is a weak CYP3A4 inducer and could slightly reduce eletriptan exposure. The clinical effect is likely small but could reduce migraine relief in some patients.
How serious is the interaction between Eletriptan and Rufinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Reassess triptan efficacy if migraine response appears reduced after rufinamide is started.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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