Drug interactions
Eletriptan + Selegiline
Severity: Moderate
Eletriptan and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a serotonergic triptan with an MAO inhibitor carries a theoretical risk of serotonin syndrome. Eletriptan is mainly cleared by CYP3A4, so a pharmacokinetic effect from selegiline is less likely.
What this interaction means in plain words
Eletriptan and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Additive serotonergic effects at 5-HT receptors and increased synaptic serotonin.
What to do
Use the lowest effective doses and monitor for serotonin toxicity features. Avoid the pairing when selegiline is given at nonselective doses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Eletriptan with Selegiline?
MediHelp rates the interaction as moderate. Eletriptan and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a serotonergic triptan with an MAO inhibitor carries a theoretical risk of serotonin syndrome. Eletriptan is mainly cleared by CYP3A4, so a pharmacokinetic effect from selegiline is less likely.
How serious is the interaction between Eletriptan and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for serotonin toxicity features. Avoid the pairing when selegiline is given at nonselective doses.
What other medicines interact with Selegiline?
MediHelp also lists interactions of Selegiline with, for example, Amitriptyline, Amoxapine, Atomoxetine. The full list is on the Selegiline page.
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