Drug interactions
Eletriptan + Sotorasib
Severity: Moderate
Eletriptan and Sotorasib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sotorasib is a P-gp inducer that may reduce the absorption of P-gp substrates such as eletriptan. It also may induce CYP3A4 modestly, further lowering exposure. This could result in reduced migraine relief.
What this interaction means in plain words
Eletriptan and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eletriptan belongs to Central Nervous System; Sotorasib belongs to Oncology.
Why it happens
Induction of P-glycoprotein and possibly CYP3A4 by sotorasib may lower eletriptan concentrations.
What to do
Monitor for reduced eletriptan efficacy. Consider switching to a triptan with a different clearance pathway if response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Eletriptan with Sotorasib?
MediHelp rates the interaction as moderate. Eletriptan and Sotorasib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sotorasib is a P-gp inducer that may reduce the absorption of P-gp substrates such as eletriptan. It also may induce CYP3A4 modestly, further lowering exposure. This could result in reduced migraine relief.
How serious is the interaction between Eletriptan and Sotorasib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced eletriptan efficacy. Consider switching to a triptan with a different clearance pathway if response is inadequate.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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