Drug interactions
Eliglustat + Lapatinib
Severity: Major
Eliglustat and Lapatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lapatinib may raise eliglustat levels through CYP3A4 inhibition, and both drugs prolong the QT interval. Higher eliglustat exposure can lead to PR, QRS and QT prolongation and arrhythmia.
What this interaction means in plain words
Eliglustat and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eliglustat belongs to Miscellaneous; Lapatinib belongs to Oncology.
Why it happens
CYP3A4 inhibition by lapatinib increases eliglustat exposure, with additive QT prolongation.
What to do
Avoid the combination where possible. If used, follow eliglustat labeling for dose reduction and monitor the ECG, especially in CYP2D6 poor or intermediate metabolizers.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Lapatinib?
MediHelp rates the interaction as major. Eliglustat and Lapatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Lapatinib may raise eliglustat levels through CYP3A4 inhibition, and both drugs prolong the QT interval. Higher eliglustat exposure can lead to PR, QRS and QT prolongation and arrhythmia.
How serious is the interaction between Eliglustat and Lapatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, follow eliglustat labeling for dose reduction and monitor the ECG, especially in CYP2D6 poor or intermediate metabolizers.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
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