Drug interactions
Eliglustat + Lidocaine-prilocaine
Severity: Minor
Eliglustat and Lidocaine-prilocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat is cleared mainly by CYP2D6 and CYP3A. Systemic lidocaine from topical lidocaine-prilocaine is small, so any rise in eliglustat exposure is expected to be minimal and unlikely to matter clinically.
What this interaction means in plain words
Eliglustat and Lidocaine-prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eliglustat belongs to Miscellaneous; Lidocaine-prilocaine belongs to Genitourinary.
Why it happens
Lidocaine has only weak potential to inhibit CYP2D6/CYP3A, and exposure from topical use is low.
What to do
No routine change is needed with topical use over intact skin at labeled doses. Monitor ECG and eliglustat response if large areas, prolonged use or systemic lidocaine are involved.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Lidocaine-prilocaine
- Lidocaine-prilocaine + Phenazopyridine Major
- Bupivacaine implant + Lidocaine-prilocaine Moderate
- Bupivacaine liposome + Lidocaine-prilocaine Moderate
- Disopyramide + Lidocaine-prilocaine Moderate
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lidocaine-prilocaine Moderate
- Lidocaine-prilocaine + Mexiletine Moderate
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Lidocaine-prilocaine?
MediHelp rates the interaction as minor. Eliglustat and Lidocaine-prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eliglustat is cleared mainly by CYP2D6 and CYP3A. Systemic lidocaine from topical lidocaine-prilocaine is small, so any rise in eliglustat exposure is expected to be minimal and unlikely to matter clinically.
How serious is the interaction between Eliglustat and Lidocaine-prilocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed with topical use over intact skin at labeled doses. Monitor ECG and eliglustat response if large areas, prolonged use or systemic lidocaine are involved.
What other medicines interact with Lidocaine-prilocaine?
MediHelp also lists interactions of Lidocaine-prilocaine with, for example, Phenazopyridine, Bupivacaine implant, Bupivacaine liposome. The full list is on the Lidocaine-prilocaine page.
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