Drug interactions
Eliglustat + Maprotiline
Severity: Major
Eliglustat and Maprotiline: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and eliglustat is metabolized by CYP2D6, so exposure may rise. Maprotiline is a CYP2D6 substrate and eliglustat inhibits CYP2D6, which may raise maprotiline levels.
What this interaction means in plain words
Eliglustat and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eliglustat belongs to Miscellaneous; Maprotiline belongs to Central Nervous System.
Why it happens
Additive QT prolongation plus CYP2D6 inhibition by eliglustat raising maprotiline exposure.
What to do
Avoid if possible. If used, obtain an ECG, consider lowering the maprotiline dose and monitor for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Maprotiline
- Arsenic trioxide + Maprotiline Contraindicated
- Disopyramide + Maprotiline Contraindicated
- Dofetilide + Maprotiline Contraindicated
- Ibutilide + Maprotiline Contraindicated
- Isocarboxazid + Maprotiline Contraindicated
- Maprotiline + Methylene blue Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Maprotiline?
MediHelp rates the interaction as major. Eliglustat and Maprotiline can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and eliglustat is metabolized by CYP2D6, so exposure may rise. Maprotiline is a CYP2D6 substrate and eliglustat inhibits CYP2D6, which may raise maprotiline levels.
How serious is the interaction between Eliglustat and Maprotiline?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If used, obtain an ECG, consider lowering the maprotiline dose and monitor for toxicity.
What other medicines interact with Maprotiline?
MediHelp also lists interactions of Maprotiline with, for example, Arsenic trioxide, Disopyramide, Dofetilide. The full list is on the Maprotiline page.
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