Drug interactions
Eliglustat + Memantine-donepezil
Severity: Moderate
Eliglustat and Memantine-donepezil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT interval prolongation, and eliglustat can raise exposure to donepezil because donepezil is partly metabolized by CYP2D6. The combined effect may increase the risk of ventricular arrhythmia including torsades de pointes, especially with other risk factors.
What this interaction means in plain words
Eliglustat and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Memantine-donepezil belongs to Central Nervous System.
Why it happens
Additive QT prolongation, plus eliglustat inhibition of CYP2D6 which may increase donepezil concentrations.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor ECG and watch for cholinergic adverse effects such as bradycardia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Memantine-donepezil
- Dronedarone + Memantine-donepezil Contraindicated
- Memantine-donepezil + Thioridazine Contraindicated
- Amantadine + Memantine-donepezil Major
- Amiodarone + Memantine-donepezil Major
- Amisulpride + Memantine-donepezil Major
- Amitriptyline + Memantine-donepezil Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Memantine-donepezil?
MediHelp rates the interaction as moderate. Eliglustat and Memantine-donepezil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT interval prolongation, and eliglustat can raise exposure to donepezil because donepezil is partly metabolized by CYP2D6. The combined effect may increase the risk of ventricular arrhythmia including torsades de pointes, especially with other risk factors.
How serious is the interaction between Eliglustat and Memantine-donepezil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Monitor ECG and watch for cholinergic adverse effects such as bradycardia.
What other medicines interact with Memantine-donepezil?
MediHelp also lists interactions of Memantine-donepezil with, for example, Dronedarone, Thioridazine, Amantadine. The full list is on the Memantine-donepezil page.
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