Drug interactions
Eliglustat + Nebivolol
Severity: Moderate
Eliglustat and Nebivolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits CYP2D6, the main enzyme clearing nebivolol, so nebivolol exposure can increase. This may lead to bradycardia and hypotension, especially in extensive metabolizers.
What this interaction means in plain words
Eliglustat and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Nebivolol belongs to Cardiovascular.
Why it happens
Inhibition of CYP2D6-mediated nebivolol metabolism raises its plasma concentrations.
What to do
Monitor heart rate and blood pressure and consider reducing the nebivolol dose, titrating to clinical effect.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nebivolol
- Acebutolol + Nebivolol Major
- Aldesleukin + Nebivolol Major
- Amiodarone + Nebivolol Major
- Atenolol-chlorthalidone + Nebivolol Major
- Atenolol + Nebivolol Major
- Betaxolol + Nebivolol Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Nebivolol?
MediHelp rates the interaction as moderate. Eliglustat and Nebivolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat inhibits CYP2D6, the main enzyme clearing nebivolol, so nebivolol exposure can increase. This may lead to bradycardia and hypotension, especially in extensive metabolizers.
How serious is the interaction between Eliglustat and Nebivolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure and consider reducing the nebivolol dose, titrating to clinical effect.
What other medicines interact with Nebivolol?
MediHelp also lists interactions of Nebivolol with, for example, Acebutolol, Aldesleukin, Amiodarone. The full list is on the Nebivolol page.
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