Drug interactions
Eliglustat + Nicardipine
Severity: Major
Eliglustat and Nicardipine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat is metabolized by CYP2D6 and CYP3A4, so inhibitors of these enzymes can raise its levels and prolong PR, QRS and QT intervals. Nicardipine is a weak to moderate CYP3A4 inhibitor, and the risk is highest in CYP2D6 poor or intermediate metabolizers.
What this interaction means in plain words
Eliglustat and Nicardipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eliglustat belongs to Miscellaneous; Nicardipine belongs to Cardiovascular.
Why it happens
Nicardipine inhibition of CYP3A4 (and possibly CYP2D6) metabolism of eliglustat, raising its plasma levels.
What to do
Avoid in CYP2D6 poor or intermediate metabolizers; in extensive metabolizers consider an eliglustat dose reduction and monitor the ECG. Choose an alternative antihypertensive if possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nicardipine
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Nicardipine?
MediHelp rates the interaction as major. Eliglustat and Nicardipine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Eliglustat is metabolized by CYP2D6 and CYP3A4, so inhibitors of these enzymes can raise its levels and prolong PR, QRS and QT intervals. Nicardipine is a weak to moderate CYP3A4 inhibitor, and the risk is highest in CYP2D6 poor or intermediate metabolizers.
How serious is the interaction between Eliglustat and Nicardipine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in CYP2D6 poor or intermediate metabolizers; in extensive metabolizers consider an eliglustat dose reduction and monitor the ECG. Choose an alternative antihypertensive if possible.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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