Drug interactions
Eliglustat + Prednisone
Severity: Minor
Eliglustat and Prednisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-glycoprotein and may modestly raise exposure to P-gp substrates. Prednisone and its active metabolite prednisolone are weak P-gp substrates, so a meaningful effect is unlikely.
What this interaction means in plain words
Eliglustat and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eliglustat belongs to Miscellaneous; Prednisone belongs to Endocrine.
Why it happens
P-glycoprotein inhibition by eliglustat may reduce efflux of prednisone/prednisolone.
What to do
No routine adjustment is needed; monitor for corticosteroid adverse effects if the patient is on high doses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Prednisone?
MediHelp rates the interaction as minor. Eliglustat and Prednisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eliglustat inhibits P-glycoprotein and may modestly raise exposure to P-gp substrates. Prednisone and its active metabolite prednisolone are weak P-gp substrates, so a meaningful effect is unlikely.
How serious is the interaction between Eliglustat and Prednisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for corticosteroid adverse effects if the patient is on high doses.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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