Drug interactions
Eliglustat + Primaquine
Severity: Moderate
Eliglustat and Primaquine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat can prolong the PR, QRS and QT intervals at high plasma concentrations, and primaquine adds a QT effect. Combined use may raise the risk of arrhythmia, particularly in patients with cardiac disease.
What this interaction means in plain words
Eliglustat and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Primaquine belongs to Anti Parasitic.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain an ECG at baseline and monitor in patients with heart disease or other QT-prolonging drugs. Correct electrolyte disturbances.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eliglustat and Primaquine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Primaquine?
MediHelp rates the interaction as moderate. Eliglustat and Primaquine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat can prolong the PR, QRS and QT intervals at high plasma concentrations, and primaquine adds a QT effect. Combined use may raise the risk of arrhythmia, particularly in patients with cardiac disease.
How serious is the interaction between Eliglustat and Primaquine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG at baseline and monitor in patients with heart disease or other QT-prolonging drugs. Correct electrolyte disturbances.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
