Drug interactions
Eliglustat + Propafenone
Severity: Major
Eliglustat and Propafenone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong cardiac conduction and the QT interval. In addition, propafenone is a CYP2D6 substrate and inhibitor, and eliglustat is a CYP2D6 substrate, so exposure to eliglustat may increase. Together this raises the risk of serious ventricular arrhythmias.
What this interaction means in plain words
Eliglustat and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eliglustat belongs to Miscellaneous; Propafenone belongs to Cardiovascular.
Why it happens
Additive effects on cardiac conduction and QT prolongation, plus CYP2D6 inhibition by propafenone raising eliglustat levels.
What to do
Avoid coadministration where possible and choose a different antiarrhythmic. If unavoidable, obtain a baseline and follow-up ECG and correct potassium and magnesium.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eliglustat and Propafenone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Propafenone
- Dofetilide + Propafenone Contraindicated
- Dronedarone + Propafenone Contraindicated
- Nilotinib + Propafenone Contraindicated
- Nirmatrelvir / ritonavir + Propafenone Contraindicated
- Nirmatrelvir + Propafenone Contraindicated
- Pimozide + Propafenone Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Propafenone?
MediHelp rates the interaction as major. Eliglustat and Propafenone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong cardiac conduction and the QT interval. In addition, propafenone is a CYP2D6 substrate and inhibitor, and eliglustat is a CYP2D6 substrate, so exposure to eliglustat may increase. Together this raises the risk of serious ventricular arrhythmias.
How serious is the interaction between Eliglustat and Propafenone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration where possible and choose a different antiarrhythmic. If unavoidable, obtain a baseline and follow-up ECG and correct potassium and magnesium.
What other medicines interact with Propafenone?
MediHelp also lists interactions of Propafenone with, for example, Dofetilide, Dronedarone, Nilotinib. The full list is on the Propafenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
