Drug interactions
Eliglustat + Saxagliptin-metformin
Severity: Minor
Eliglustat and Saxagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-glycoprotein and could increase saxagliptin exposure. The clinical significance is likely modest because saxagliptin has a wide therapeutic margin.
What this interaction means in plain words
Eliglustat and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eliglustat belongs to Miscellaneous; Saxagliptin-metformin belongs to Endocrine.
Why it happens
Eliglustat inhibits P-glycoprotein, possibly reducing efflux of saxagliptin.
What to do
Monitor for saxagliptin adverse effects such as hypoglycemia or peripheral edema and adjust the dose if they occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Saxagliptin-metformin
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Saxagliptin-metformin?
MediHelp rates the interaction as minor. Eliglustat and Saxagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eliglustat inhibits P-glycoprotein and could increase saxagliptin exposure. The clinical significance is likely modest because saxagliptin has a wide therapeutic margin.
How serious is the interaction between Eliglustat and Saxagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for saxagliptin adverse effects such as hypoglycemia or peripheral edema and adjust the dose if they occur.
What other medicines interact with Saxagliptin-metformin?
MediHelp also lists interactions of Saxagliptin-metformin with, for example, Atazanavir, Clozapine, Contrast media. The full list is on the Saxagliptin-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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