Drug interactions
Eliglustat + Sertraline
Severity: Moderate
Eliglustat and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline is a weak to moderate, dose-dependent CYP2D6 inhibitor that can raise eliglustat exposure. Elevated eliglustat levels can prolong cardiac conduction intervals and cause arrhythmia.
What this interaction means in plain words
Eliglustat and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Sertraline belongs to Central Nervous System.
Why it happens
Sertraline inhibition of CYP2D6 reduces eliglustat metabolism.
What to do
Follow labeling for dose reduction with CYP2D6 inhibitors and monitor ECG. Avoid if the patient is also taking a CYP3A inhibitor or is a CYP2D6 poor metaboliser.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Sertraline?
MediHelp rates the interaction as moderate. Eliglustat and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline is a weak to moderate, dose-dependent CYP2D6 inhibitor that can raise eliglustat exposure. Elevated eliglustat levels can prolong cardiac conduction intervals and cause arrhythmia.
How serious is the interaction between Eliglustat and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Follow labeling for dose reduction with CYP2D6 inhibitors and monitor ECG. Avoid if the patient is also taking a CYP3A inhibitor or is a CYP2D6 poor metaboliser.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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