Drug interactions
Eliglustat + Sitagliptin
Severity: Minor
Eliglustat and Sitagliptin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-glycoprotein and may modestly raise sitagliptin exposure. Sitagliptin has a wide therapeutic margin, so clinically significant effects are unlikely.
What this interaction means in plain words
Eliglustat and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eliglustat belongs to Miscellaneous; Sitagliptin belongs to Endocrine.
Why it happens
Inhibition of P-glycoprotein efflux by eliglustat reduces the transport of sitagliptin and increases its concentrations.
What to do
No routine dose change is needed. Monitor for sitagliptin adverse effects such as gastrointestinal upset or hypoglycemia if combined with a sulfonylurea or insulin.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sitagliptin
- Albiglutide + Sitagliptin Moderate
- Amlodipine-benazepril + Sitagliptin Moderate
- Aripiprazole + Sitagliptin Moderate
- Asenapine + Sitagliptin Moderate
- Benazepril + Sitagliptin Moderate
- Captopril-hydrochlorothiazide + Sitagliptin Moderate
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Sitagliptin?
MediHelp rates the interaction as minor. Eliglustat and Sitagliptin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eliglustat inhibits P-glycoprotein and may modestly raise sitagliptin exposure. Sitagliptin has a wide therapeutic margin, so clinically significant effects are unlikely.
How serious is the interaction between Eliglustat and Sitagliptin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed. Monitor for sitagliptin adverse effects such as gastrointestinal upset or hypoglycemia if combined with a sulfonylurea or insulin.
What other medicines interact with Sitagliptin?
MediHelp also lists interactions of Sitagliptin with, for example, Albiglutide, Amlodipine-benazepril, Aripiprazole. The full list is on the Sitagliptin page.
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