Drug interactions
Eliglustat + Thioridazine
Severity: Contraindicated
Eliglustat and Thioridazine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thioridazine inhibits CYP2D6, which is the main route of eliglustat metabolism, and both drugs prolong the QT interval. Eliglustat exposure rises, which increases the risk of dangerous arrhythmias.
What this interaction means in plain words
Eliglustat and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Eliglustat belongs to Miscellaneous; Thioridazine belongs to Central Nervous System.
Why it happens
CYP2D6 inhibition raises eliglustat levels, with additive QT prolongation.
What to do
Avoid the combination and use an antipsychotic without QT or CYP2D6 effects. If it cannot be avoided, perform ECG monitoring and consider reducing the eliglustat dose.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Thioridazine?
MediHelp rates the interaction as contraindicated. Eliglustat and Thioridazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Thioridazine inhibits CYP2D6, which is the main route of eliglustat metabolism, and both drugs prolong the QT interval. Eliglustat exposure rises, which increases the risk of dangerous arrhythmias.
How serious is the interaction between Eliglustat and Thioridazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use an antipsychotic without QT or CYP2D6 effects. If it cannot be avoided, perform ECG monitoring and consider reducing the eliglustat dose.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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