Drug interactions
Eliglustat + Tranylcypromine
Severity: Moderate
Eliglustat and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tranylcypromine has been listed as a CYP2D6 inhibitor in some references, which could raise eliglustat concentrations, but its inhibitory effect is weak and the evidence is limited. Raised eliglustat levels can prolong PR, QRS and QT intervals, but a contraindication is not well supported for this pair.
What this interaction means in plain words
Eliglustat and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Tranylcypromine belongs to Central Nervous System.
Why it happens
Possible weak CYP2D6 inhibition by tranylcypromine reducing eliglustat metabolism.
What to do
Monitor ECG and for cardiac symptoms when starting the combination, and consider reducing eliglustat to once daily in extensive and intermediate metabolizers if exposure appears increased.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Tranylcypromine?
MediHelp rates the interaction as moderate. Eliglustat and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tranylcypromine has been listed as a CYP2D6 inhibitor in some references, which could raise eliglustat concentrations, but its inhibitory effect is weak and the evidence is limited. Raised eliglustat levels can prolong PR, QRS and QT intervals, but a contraindication is not well supported for this pair.
How serious is the interaction between Eliglustat and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and for cardiac symptoms when starting the combination, and consider reducing eliglustat to once daily in extensive and intermediate metabolizers if exposure appears increased.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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