Drug interactions
Eliglustat + Verapamil
Severity: Major
Eliglustat and Verapamil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil is a moderate CYP3A4 inhibitor, and eliglustat is metabolized by CYP2D6 and CYP3A4. Eliglustat levels can rise, increasing the risk of PR, QRS and QT prolongation, and verapamil also affects cardiac conduction.
What this interaction means in plain words
Eliglustat and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eliglustat belongs to Miscellaneous; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4, reducing eliglustat clearance, with additive conduction effects.
What to do
Avoid in CYP2D6 intermediate or poor metabolizers. In extensive metabolizers, reduce eliglustat to 84 mg once daily and monitor ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Verapamil?
MediHelp rates the interaction as major. Eliglustat and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Verapamil is a moderate CYP3A4 inhibitor, and eliglustat is metabolized by CYP2D6 and CYP3A4. Eliglustat levels can rise, increasing the risk of PR, QRS and QT prolongation, and verapamil also affects cardiac conduction.
How serious is the interaction between Eliglustat and Verapamil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in CYP2D6 intermediate or poor metabolizers. In extensive metabolizers, reduce eliglustat to 84 mg once daily and monitor ECG.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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