Drug interactions
Eliglustat + Vinblastine
Severity: Moderate
Eliglustat and Vinblastine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eliglustat inhibits P-glycoprotein and may raise vinblastine concentrations. Increased exposure could worsen myelosuppression and neurotoxicity.
What this interaction means in plain words
Eliglustat and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eliglustat belongs to Miscellaneous; Vinblastine belongs to Oncology.
Why it happens
P-glycoprotein inhibition by eliglustat reduces vinblastine efflux and clearance.
What to do
Monitor blood counts and neurotoxicity. Reduce the vinblastine dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eliglustat and Vinblastine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Vinblastine
Other interactions of Eliglustat
- Amiodarone + Eliglustat Contraindicated
- Clarithromycin + Eliglustat Contraindicated
- Dronedarone + Eliglustat Contraindicated
- Eliglustat + Itraconazole Contraindicated
- Eliglustat + Ketoconazole Contraindicated
- Eliglustat + Pimozide Contraindicated
Frequently asked questions
Can I take Eliglustat with Vinblastine?
MediHelp rates the interaction as moderate. Eliglustat and Vinblastine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eliglustat inhibits P-glycoprotein and may raise vinblastine concentrations. Increased exposure could worsen myelosuppression and neurotoxicity.
How serious is the interaction between Eliglustat and Vinblastine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neurotoxicity. Reduce the vinblastine dose if toxicity occurs.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
