Drug interactions
Elranatamab + Quinidine
Severity: Moderate
Elranatamab and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elranatamab can trigger cytokine release syndrome, and the raised cytokines temporarily suppress CYP450 activity. Exposure to quinidine, a narrow therapeutic index CYP3A4 substrate, may therefore rise, increasing the risk of QT prolongation and arrhythmia. The risk is greatest during step-up dosing and for some days after treatment doses.
What this interaction means in plain words
Elranatamab and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elranatamab belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Cytokine-mediated downregulation of CYP3A4 activity during cytokine release syndrome reduces quinidine clearance.
What to do
Monitor quinidine concentrations and ECG/QTc during elranatamab step-up dosing and for about 14 days after, and during any CRS episode. Reduce the quinidine dose if toxicity or QTc prolongation appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Elranatamab
- Elranatamab + Ergotamine Major
- Elranatamab + Pimozide Major
- Bendamustine + Elranatamab Moderate
- Carbamazepine + Elranatamab Moderate
- Clomipramine + Elranatamab Moderate
- Clozapine + Elranatamab Moderate
Frequently asked questions
Can I take Elranatamab with Quinidine?
MediHelp rates the interaction as moderate. Elranatamab and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Elranatamab can trigger cytokine release syndrome, and the raised cytokines temporarily suppress CYP450 activity. Exposure to quinidine, a narrow therapeutic index CYP3A4 substrate, may therefore rise, increasing the risk of QT prolongation and arrhythmia. The risk is greatest during step-up dosing and for some days after treatment doses.
How serious is the interaction between Elranatamab and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor quinidine concentrations and ECG/QTc during elranatamab step-up dosing and for about 14 days after, and during any CRS episode. Reduce the quinidine dose if toxicity or QTc prolongation appears.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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