Drug interactions
Elranatamab + Thioridazine
Severity: Moderate
Elranatamab and Thioridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytokine release syndrome from elranatamab can transiently suppress CYP enzymes, which may raise levels of sensitive substrates. Thioridazine has a narrow safety margin because of QT prolongation, so higher exposure could be hazardous.
What this interaction means in plain words
Elranatamab and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Elranatamab belongs to Oncology; Thioridazine belongs to Central Nervous System.
Why it happens
Cytokine-mediated suppression of CYP450 activity during cytokine release syndrome raises substrate exposure.
What to do
Monitor for thioridazine toxicity and ECG changes during step-up dosing and for the period after cytokine release syndrome. Consider holding or reducing thioridazine or using an alternative drug.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Other interactions of Elranatamab
- Elranatamab + Ergotamine Major
- Elranatamab + Pimozide Major
- Bendamustine + Elranatamab Moderate
- Carbamazepine + Elranatamab Moderate
- Clomipramine + Elranatamab Moderate
- Clozapine + Elranatamab Moderate
Frequently asked questions
Can I take Elranatamab with Thioridazine?
MediHelp rates the interaction as moderate. Elranatamab and Thioridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine release syndrome from elranatamab can transiently suppress CYP enzymes, which may raise levels of sensitive substrates. Thioridazine has a narrow safety margin because of QT prolongation, so higher exposure could be hazardous.
How serious is the interaction between Elranatamab and Thioridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for thioridazine toxicity and ECG changes during step-up dosing and for the period after cytokine release syndrome. Consider holding or reducing thioridazine or using an alternative drug.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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