Drug interactions
Elranatamab + Valproic acid
Severity: Minor
Elranatamab and Valproic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Elranatamab causes cytokine release syndrome, and elevated cytokines can transiently suppress CYP enzyme activity. Valproate is mainly cleared by glucuronidation and beta-oxidation, with only a minor CYP contribution, so a clinically significant rise in levels is unlikely.
What this interaction means in plain words
Elranatamab and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Elranatamab belongs to Oncology; Valproic acid belongs to Central Nervous System.
Why it happens
Cytokine-mediated suppression of CYP enzymes during cytokine release syndrome; limited relevance to valproate.
What to do
No empiric dose change is needed. Monitor for valproate toxicity or check levels if the patient has significant cytokine release syndrome.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Elranatamab
- Elranatamab + Ergotamine Major
- Elranatamab + Pimozide Major
- Bendamustine + Elranatamab Moderate
- Carbamazepine + Elranatamab Moderate
- Clomipramine + Elranatamab Moderate
- Clozapine + Elranatamab Moderate
Frequently asked questions
Can I take Elranatamab with Valproic acid?
MediHelp rates the interaction as minor. Elranatamab and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Elranatamab causes cytokine release syndrome, and elevated cytokines can transiently suppress CYP enzyme activity. Valproate is mainly cleared by glucuronidation and beta-oxidation, with only a minor CYP contribution, so a clinically significant rise in levels is unlikely.
How serious is the interaction between Elranatamab and Valproic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Monitor for valproate toxicity or check levels if the patient has significant cytokine release syndrome.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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