Drug interactions
Eltrombopag + Eluxadoline
Severity: Moderate
Eltrombopag and Eluxadoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits OATP1B1, and eluxadoline is an OATP1B1 substrate, so eluxadoline exposure may increase. Higher levels raise the risk of adverse effects such as constipation, nausea, abdominal pain and pancreatitis.
What this interaction means in plain words
Eltrombopag and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eltrombopag belongs to Miscellaneous; Eluxadoline belongs to Gastrointestinal Tract.
Why it happens
Eltrombopag inhibits hepatic OATP1B1 uptake, which reduces eluxadoline clearance.
What to do
Reduce eluxadoline to 75 mg twice daily when it is given with an OATP1B1 inhibitor such as eltrombopag. Monitor for constipation and abdominal pain.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eltrombopag with Eluxadoline?
MediHelp rates the interaction as moderate. Eltrombopag and Eluxadoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eltrombopag inhibits OATP1B1, and eluxadoline is an OATP1B1 substrate, so eluxadoline exposure may increase. Higher levels raise the risk of adverse effects such as constipation, nausea, abdominal pain and pancreatitis.
How serious is the interaction between Eltrombopag and Eluxadoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce eluxadoline to 75 mg twice daily when it is given with an OATP1B1 inhibitor such as eltrombopag. Monitor for constipation and abdominal pain.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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