Drug interactions
Eltrombopag + Fluvoxamine
Severity: Minor
Eltrombopag and Fluvoxamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag is cleared partly through CYP1A2 among other pathways, so fluvoxamine might raise its levels. The effect is not well characterized and is likely modest given multiple elimination routes.
What this interaction means in plain words
Eltrombopag and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eltrombopag belongs to Miscellaneous; Fluvoxamine belongs to Central Nervous System.
Why it happens
Possible CYP1A2 inhibition by fluvoxamine reducing eltrombopag metabolism.
What to do
Monitor platelet counts and liver tests, and adjust the eltrombopag dose based on response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Fluvoxamine?
MediHelp rates the interaction as minor. Eltrombopag and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag is cleared partly through CYP1A2 among other pathways, so fluvoxamine might raise its levels. The effect is not well characterized and is likely modest given multiple elimination routes.
How serious is the interaction between Eltrombopag and Fluvoxamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and liver tests, and adjust the eltrombopag dose based on response.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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