Drug interactions
Eltrombopag + Hydromorphone
Severity: Minor
Eltrombopag and Hydromorphone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits UGT enzymes in vitro, and hydromorphone is eliminated mainly by UGT2B7 glucuronidation. A rise in hydromorphone exposure is theoretically possible, but clinical significance has not been shown.
What this interaction means in plain words
Eltrombopag and Hydromorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eltrombopag belongs to Miscellaneous; Hydromorphone belongs to Musculoskeletal.
Why it happens
Possible inhibition of UGT-mediated glucuronidation of hydromorphone, predicted from in vitro data.
What to do
No dose change is routinely needed; monitor for excess sedation or opioid effects when starting eltrombopag.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydromorphone
- Alvimopan + Hydromorphone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Hydromorphone + Isocarboxazid Contraindicated
- Hydromorphone + Olanzapine / samidorphan Contraindicated
- Hydromorphone + Phenelzine Contraindicated
- Hydromorphone + Tranylcypromine Contraindicated
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Hydromorphone?
MediHelp rates the interaction as minor. Eltrombopag and Hydromorphone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits UGT enzymes in vitro, and hydromorphone is eliminated mainly by UGT2B7 glucuronidation. A rise in hydromorphone exposure is theoretically possible, but clinical significance has not been shown.
How serious is the interaction between Eltrombopag and Hydromorphone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed; monitor for excess sedation or opioid effects when starting eltrombopag.
What other medicines interact with Hydromorphone?
MediHelp also lists interactions of Hydromorphone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydromorphone page.
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