Drug interactions
Eltrombopag + Letermovir
Severity: Moderate
Eltrombopag and Letermovir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Letermovir is an OATP1B1/3 substrate, and eltrombopag inhibits OATP1B1. Letermovir plasma concentrations may rise modestly.
What this interaction means in plain words
Eltrombopag and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eltrombopag belongs to Miscellaneous; Letermovir belongs to Anti Virals.
Why it happens
Eltrombopag inhibits OATP1B1/3-mediated hepatic uptake of letermovir.
What to do
Monitor for letermovir adverse effects such as gastrointestinal symptoms and liver enzyme changes. No routine dose adjustment is recommended.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Other interactions of Letermovir
- Ergotamine + Letermovir Contraindicated
- Letermovir + Pimozide Contraindicated
- Apalutamide + Letermovir Major
- Atorvastatin + Letermovir Major
- Carbamazepine + Letermovir Major
- Colchicine + Letermovir Major
Frequently asked questions
Can I take Eltrombopag with Letermovir?
MediHelp rates the interaction as moderate. Eltrombopag and Letermovir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Letermovir is an OATP1B1/3 substrate, and eltrombopag inhibits OATP1B1. Letermovir plasma concentrations may rise modestly.
How serious is the interaction between Eltrombopag and Letermovir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for letermovir adverse effects such as gastrointestinal symptoms and liver enzyme changes. No routine dose adjustment is recommended.
What other medicines interact with Eltrombopag?
MediHelp also lists interactions of Eltrombopag with, for example, Alpelisib, Aluminum hydroxide, Amobarbital. The full list is on the Eltrombopag page.
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