Drug interactions
Eltrombopag + Mefenamic acid
Severity: Minor
Eltrombopag and Mefenamic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits UGT enzymes, and mefenamic acid is partly cleared by glucuronidation, so exposure to mefenamic acid could rise. The clinical significance is uncertain and likely small.
What this interaction means in plain words
Eltrombopag and Mefenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eltrombopag belongs to Miscellaneous; Mefenamic acid belongs to Musculoskeletal.
Why it happens
Inhibition of UGT-mediated glucuronidation of mefenamic acid by eltrombopag.
What to do
No routine adjustment is needed; monitor for NSAID adverse effects such as GI upset. Note that NSAIDs may add bleeding risk in thrombocytopenic patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mefenamic acid
- Ketorolac intranasal + Mefenamic acid Contraindicated
- Ketorolac + Mefenamic acid Contraindicated
- Aceclofenac + Mefenamic acid Major
- Acemetacin + Mefenamic acid Major
- Acetylsalicylic acid + Mefenamic acid Major
- Alteplase + Mefenamic acid Major
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Mefenamic acid?
MediHelp rates the interaction as minor. Eltrombopag and Mefenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits UGT enzymes, and mefenamic acid is partly cleared by glucuronidation, so exposure to mefenamic acid could rise. The clinical significance is uncertain and likely small.
How serious is the interaction between Eltrombopag and Mefenamic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for NSAID adverse effects such as GI upset. Note that NSAIDs may add bleeding risk in thrombocytopenic patients.
What other medicines interact with Mefenamic acid?
MediHelp also lists interactions of Mefenamic acid with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Mefenamic acid page.
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