Drug interactions
Eltrombopag + Meperidine
Severity: Minor
Eltrombopag and Meperidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits UGT enzymes in vitro, but meperidine is cleared mainly by esterases and CYP-mediated N-demethylation rather than glucuronidation. A clinically meaningful rise in meperidine exposure is therefore not established.
What this interaction means in plain words
Eltrombopag and Meperidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eltrombopag belongs to Miscellaneous; Meperidine belongs to Musculoskeletal.
Why it happens
Theoretical UGT inhibition by eltrombopag; relevance to meperidine metabolism is unproven.
What to do
No routine adjustment is needed; titrate meperidine to clinical response and watch for excess sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Meperidine
- Alvimopan + Meperidine Contraindicated
- Isocarboxazid + Meperidine Contraindicated
- Meperidine + Methylene blue Contraindicated
- Meperidine + Olanzapine / samidorphan Contraindicated
- Meperidine + Phenelzine Contraindicated
- Meperidine + Procarbazine Contraindicated
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Meperidine?
MediHelp rates the interaction as minor. Eltrombopag and Meperidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits UGT enzymes in vitro, but meperidine is cleared mainly by esterases and CYP-mediated N-demethylation rather than glucuronidation. A clinically meaningful rise in meperidine exposure is therefore not established.
How serious is the interaction between Eltrombopag and Meperidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; titrate meperidine to clinical response and watch for excess sedation.
What other medicines interact with Meperidine?
MediHelp also lists interactions of Meperidine with, for example, Alvimopan, Isocarboxazid, Methylene blue. The full list is on the Meperidine page.
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