Drug interactions
Eltrombopag + Pravastatin
Severity: Moderate
Eltrombopag and Pravastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits OATP1B1 and can increase pravastatin exposure, which may raise the risk of myopathy. The effect is generally modest.
What this interaction means in plain words
Eltrombopag and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eltrombopag belongs to Miscellaneous; Pravastatin belongs to Cardiovascular.
Why it happens
Eltrombopag inhibits the OATP1B1 uptake transporter, reducing hepatic uptake of pravastatin.
What to do
Consider a reduced pravastatin dose and monitor for muscle symptoms, checking CK if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Pravastatin?
MediHelp rates the interaction as moderate. Eltrombopag and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eltrombopag inhibits OATP1B1 and can increase pravastatin exposure, which may raise the risk of myopathy. The effect is generally modest.
How serious is the interaction between Eltrombopag and Pravastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a reduced pravastatin dose and monitor for muscle symptoms, checking CK if they occur.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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