Drug interactions
Eltrombopag + Rosuvastatin
Severity: Moderate
Eltrombopag and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits OATP1B1 and BCRP and raises rosuvastatin exposure. This increases the risk of myopathy.
What this interaction means in plain words
Eltrombopag and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eltrombopag belongs to Miscellaneous; Rosuvastatin belongs to Cardiovascular.
Why it happens
Inhibition of OATP1B1 and BCRP increases rosuvastatin systemic exposure.
What to do
Reduce the rosuvastatin dose when given with eltrombopag, as per eltrombopag labeling, and monitor for muscle symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Rosuvastatin?
MediHelp rates the interaction as moderate. Eltrombopag and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eltrombopag inhibits OATP1B1 and BCRP and raises rosuvastatin exposure. This increases the risk of myopathy.
How serious is the interaction between Eltrombopag and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce the rosuvastatin dose when given with eltrombopag, as per eltrombopag labeling, and monitor for muscle symptoms.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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