Drug interactions
Eltrombopag + Tapentadol
Severity: Minor
Eltrombopag and Tapentadol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eltrombopag inhibits UGT1A1 and other UGT enzymes in vitro, and tapentadol is cleared mainly by UGT-mediated glucuronidation. Exposure to tapentadol could therefore rise, but clinical significance has not been established.
What this interaction means in plain words
Eltrombopag and Tapentadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eltrombopag belongs to Miscellaneous; Tapentadol belongs to Musculoskeletal.
Why it happens
Possible inhibition of UGT-mediated tapentadol glucuronidation by eltrombopag, based on in vitro data.
What to do
No dose change is needed routinely; monitor for increased opioid effects such as sedation or nausea when eltrombopag is started.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tapentadol
- Calcium / magnesium / potassium / sodium oxybates + Tapentadol Contraindicated
- Isocarboxazid + Tapentadol Contraindicated
- Linezolid + Tapentadol Contraindicated
- Methylene blue + Tapentadol Contraindicated
- Olanzapine / samidorphan + Tapentadol Contraindicated
- Phenelzine + Tapentadol Contraindicated
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Eltrombopag with Tapentadol?
MediHelp rates the interaction as minor. Eltrombopag and Tapentadol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eltrombopag inhibits UGT1A1 and other UGT enzymes in vitro, and tapentadol is cleared mainly by UGT-mediated glucuronidation. Exposure to tapentadol could therefore rise, but clinical significance has not been established.
How serious is the interaction between Eltrombopag and Tapentadol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed routinely; monitor for increased opioid effects such as sedation or nausea when eltrombopag is started.
What other medicines interact with Tapentadol?
MediHelp also lists interactions of Tapentadol with, for example, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid, Linezolid. The full list is on the Tapentadol page.
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