Drug interactions
Eluxadoline + Fluoxetine
Severity: Minor
Eluxadoline and Fluoxetine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoxetine strongly inhibits CYP2D6, and the metabolic handling of eluxadoline is incompletely characterised. Exposure to eluxadoline may therefore rise, increasing the likelihood of its adverse effects such as constipation, nausea and abdominal pain.
What this interaction means in plain words
Eluxadoline and Fluoxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eluxadoline belongs to Gastrointestinal Tract; Fluoxetine belongs to Central Nervous System.
Why it happens
Fluoxetine inhibits CYP2D6, which may reduce the clearance of eluxadoline, though its contribution to eluxadoline metabolism is not well established.
What to do
Monitor for eluxadoline adverse effects such as constipation and abdominal pain, and reduce the dose or stop if they develop.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eluxadoline and Fluoxetine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Fluoxetine
- Fluoxetine + Isocarboxazid Contraindicated
- Fluoxetine + Mavacamten Contraindicated
- Fluoxetine + Methylene blue Contraindicated
- Fluoxetine + Phenelzine Contraindicated
- Fluoxetine + Pimozide Contraindicated
- Fluoxetine + Rasagiline Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Fluoxetine?
MediHelp rates the interaction as minor. Eluxadoline and Fluoxetine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fluoxetine strongly inhibits CYP2D6, and the metabolic handling of eluxadoline is incompletely characterised. Exposure to eluxadoline may therefore rise, increasing the likelihood of its adverse effects such as constipation, nausea and abdominal pain.
How serious is the interaction between Eluxadoline and Fluoxetine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for eluxadoline adverse effects such as constipation and abdominal pain, and reduce the dose or stop if they develop.
What other medicines interact with Fluoxetine?
MediHelp also lists interactions of Fluoxetine with, for example, Isocarboxazid, Mavacamten, Methylene blue. The full list is on the Fluoxetine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
