Drug interactions
Eluxadoline + Imatinib
Severity: Minor
Eluxadoline and Imatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline inhibits OATP1B1 and BCRP and may modestly raise exposure to imatinib, a BCRP substrate. The clinical effect is likely small.
What this interaction means in plain words
Eluxadoline and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eluxadoline belongs to Gastrointestinal Tract; Imatinib belongs to Oncology.
Why it happens
Eluxadoline inhibits BCRP-mediated efflux of imatinib.
What to do
No routine adjustment is needed; monitor for imatinib adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Imatinib?
MediHelp rates the interaction as minor. Eluxadoline and Imatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eluxadoline inhibits OATP1B1 and BCRP and may modestly raise exposure to imatinib, a BCRP substrate. The clinical effect is likely small.
How serious is the interaction between Eluxadoline and Imatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for imatinib adverse effects.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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