Drug interactions
Eluxadoline + Lapatinib
Severity: Moderate
Eluxadoline and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline inhibits BCRP and may increase systemic exposure to lapatinib, a BCRP substrate. This could raise lapatinib adverse effects, including diarrhea, rash and hepatotoxicity.
What this interaction means in plain words
Eluxadoline and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Lapatinib belongs to Oncology.
Why it happens
Eluxadoline inhibits BCRP and OATP-related transport, increasing lapatinib exposure.
What to do
Monitor for lapatinib toxicity and liver tests. Eluxadoline treats diarrhea, so also watch for constipation or masking of lapatinib-related diarrhea.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Lapatinib?
MediHelp rates the interaction as moderate. Eluxadoline and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline inhibits BCRP and may increase systemic exposure to lapatinib, a BCRP substrate. This could raise lapatinib adverse effects, including diarrhea, rash and hepatotoxicity.
How serious is the interaction between Eluxadoline and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lapatinib toxicity and liver tests. Eluxadoline treats diarrhea, so also watch for constipation or masking of lapatinib-related diarrhea.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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