Drug interactions
Eluxadoline + Levofloxacin
Severity: Minor
Eluxadoline and Levofloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline inhibits OATP1B1 and may raise exposure to substrates of that transporter. Levofloxacin is not primarily an OATP1B1 substrate and is mostly renally eliminated, so a clinically important effect is unlikely.
What this interaction means in plain words
Eluxadoline and Levofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eluxadoline belongs to Gastrointestinal Tract; Levofloxacin belongs to Anti Bacterial.
Why it happens
Possible OATP1B1 inhibition by eluxadoline; relevance to levofloxacin is not established.
What to do
No dose adjustment is needed. Monitor for levofloxacin adverse effects if clinically unusual symptoms occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eluxadoline and Levofloxacin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Levofloxacin
- Dronedarone + Levofloxacin Contraindicated
- Ibutilide + Levofloxacin Contraindicated
- Levofloxacin + Thioridazine Contraindicated
- Levofloxacin + Vandetanib Contraindicated
- Levofloxacin + Ziprasidone Contraindicated
- Adagrasib + Levofloxacin Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Levofloxacin?
MediHelp rates the interaction as minor. Eluxadoline and Levofloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eluxadoline inhibits OATP1B1 and may raise exposure to substrates of that transporter. Levofloxacin is not primarily an OATP1B1 substrate and is mostly renally eliminated, so a clinically important effect is unlikely.
How serious is the interaction between Eluxadoline and Levofloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor for levofloxacin adverse effects if clinically unusual symptoms occur.
What other medicines interact with Levofloxacin?
MediHelp also lists interactions of Levofloxacin with, for example, Dronedarone, Ibutilide, Thioridazine. The full list is on the Levofloxacin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
