Drug interactions
Eluxadoline + Methoxsalen
Severity: Moderate
Eluxadoline and Methoxsalen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methoxsalen is a strong CYP1A2 inhibitor, and eluxadoline metabolism is incompletely characterized, so exposure could increase. Higher eluxadoline levels might increase constipation, nausea or pancreatitis risk.
What this interaction means in plain words
Eluxadoline and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Methoxsalen belongs to Anti Fungals.
Why it happens
Possible CYP1A2 inhibition by methoxsalen reducing eluxadoline clearance.
What to do
Monitor for gastrointestinal adverse effects and abdominal pain. Consider the lower eluxadoline dose if the combination is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methoxsalen
- Fezolinetant + Methoxsalen Contraindicated
- Demeclocycline + Methoxsalen Major
- Fedratinib + Methoxsalen Major
- Methoxsalen + Pirfenidone Major
- Methoxsalen + Tasimelteon Major
- Adapalene + Methoxsalen Moderate
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Methoxsalen?
MediHelp rates the interaction as moderate. Eluxadoline and Methoxsalen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Methoxsalen is a strong CYP1A2 inhibitor, and eluxadoline metabolism is incompletely characterized, so exposure could increase. Higher eluxadoline levels might increase constipation, nausea or pancreatitis risk.
How serious is the interaction between Eluxadoline and Methoxsalen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal adverse effects and abdominal pain. Consider the lower eluxadoline dose if the combination is needed.
What other medicines interact with Methoxsalen?
MediHelp also lists interactions of Methoxsalen with, for example, Fezolinetant, Demeclocycline, Fedratinib. The full list is on the Methoxsalen page.
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