Drug interactions
Eluxadoline + Mexiletine
Severity: Minor
Eluxadoline and Mexiletine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mexiletine is a CYP1A2 substrate and inhibitor, but eluxadoline is not known to be primarily metabolized by CYP1A2, so an interaction is only speculative. The legacy caution is based on incomplete metabolic data for eluxadoline.
What this interaction means in plain words
Eluxadoline and Mexiletine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eluxadoline belongs to Gastrointestinal Tract; Mexiletine belongs to Cardiovascular.
Why it happens
Theoretical CYP1A2 inhibition by mexiletine; the mechanism is not established for eluxadoline.
What to do
No specific adjustment is needed; monitor for eluxadoline adverse effects such as constipation or abdominal pain.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mexiletine
- Fezolinetant + Mexiletine Contraindicated
- Mexiletine + Pimozide Contraindicated
- Alosetron + Mexiletine Major
- Amiodarone + Mexiletine Major
- Clozapine + Mexiletine Major
- Cobicistat + Mexiletine Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Mexiletine?
MediHelp rates the interaction as minor. Eluxadoline and Mexiletine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Mexiletine is a CYP1A2 substrate and inhibitor, but eluxadoline is not known to be primarily metabolized by CYP1A2, so an interaction is only speculative. The legacy caution is based on incomplete metabolic data for eluxadoline.
How serious is the interaction between Eluxadoline and Mexiletine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific adjustment is needed; monitor for eluxadoline adverse effects such as constipation or abdominal pain.
What other medicines interact with Mexiletine?
MediHelp also lists interactions of Mexiletine with, for example, Fezolinetant, Pimozide, Alosetron. The full list is on the Mexiletine page.
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