Drug interactions
Eluxadoline + Mifepristone
Severity: Moderate
Eluxadoline and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone may increase eluxadoline exposure through inhibition of hepatic uptake transport. Higher levels raise the risk of pancreatitis, constipation and CNS effects.
What this interaction means in plain words
Eluxadoline and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of OATP1B1-mediated hepatic uptake is suspected to increase eluxadoline levels.
What to do
Reduce eluxadoline to 75 mg twice daily if the combination is needed and monitor for abdominal pain, constipation and pancreatitis symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Mifepristone?
MediHelp rates the interaction as moderate. Eluxadoline and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone may increase eluxadoline exposure through inhibition of hepatic uptake transport. Higher levels raise the risk of pancreatitis, constipation and CNS effects.
How serious is the interaction between Eluxadoline and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce eluxadoline to 75 mg twice daily if the combination is needed and monitor for abdominal pain, constipation and pancreatitis symptoms.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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