Drug interactions
Eluxadoline + Mitoxantrone
Severity: Moderate
Eluxadoline and Mitoxantrone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline inhibits BCRP and may increase mitoxantrone exposure, with possible greater myelosuppression. Clinical data are limited.
What this interaction means in plain words
Eluxadoline and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Mitoxantrone belongs to Central Nervous System.
Why it happens
Inhibition of BCRP-mediated efflux by eluxadoline raises mitoxantrone absorption.
What to do
Monitor blood counts and consider alternatives to eluxadoline during mitoxantrone cycles.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mitoxantrone
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Mitoxantrone?
MediHelp rates the interaction as moderate. Eluxadoline and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline inhibits BCRP and may increase mitoxantrone exposure, with possible greater myelosuppression. Clinical data are limited.
How serious is the interaction between Eluxadoline and Mitoxantrone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and consider alternatives to eluxadoline during mitoxantrone cycles.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
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