Drug interactions
Eluxadoline + Nalbuphine
Severity: Moderate
Eluxadoline and Nalbuphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eluxadoline is a mu opioid agonist used for IBS with diarrhea, and its labeling warns against use with other constipating drugs because of the risk of serious constipation complications. Nalbuphine has opioid effects on gut motility and may add to this risk.
What this interaction means in plain words
Eluxadoline and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Nalbuphine belongs to Musculoskeletal.
Why it happens
Additive opioid-mediated reduction in gastrointestinal motility.
What to do
Avoid regular concurrent use where possible. If combined, monitor for constipation and stop eluxadoline if severe constipation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Nalbuphine?
MediHelp rates the interaction as moderate. Eluxadoline and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eluxadoline is a mu opioid agonist used for IBS with diarrhea, and its labeling warns against use with other constipating drugs because of the risk of serious constipation complications. Nalbuphine has opioid effects on gut motility and may add to this risk.
How serious is the interaction between Eluxadoline and Nalbuphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular concurrent use where possible. If combined, monitor for constipation and stop eluxadoline if severe constipation develops.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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