Drug interactions
Eluxadoline + Paclitaxel
Severity: Moderate
Eluxadoline and Paclitaxel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paclitaxel may inhibit OATP1B1 and raise eluxadoline exposure, which may increase adverse effects such as constipation, nausea and pancreatitis. Eluxadoline is also associated with sphincter of Oddi spasm.
What this interaction means in plain words
Eluxadoline and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Paclitaxel belongs to Oncology.
Why it happens
Inhibition of OATP1B1-mediated hepatic uptake of eluxadoline.
What to do
Reduce eluxadoline to 75 mg twice daily if given with OATP1B1 inhibitors, and monitor for abdominal pain, constipation and pancreatitis symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paclitaxel
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Paclitaxel?
MediHelp rates the interaction as moderate. Eluxadoline and Paclitaxel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paclitaxel may inhibit OATP1B1 and raise eluxadoline exposure, which may increase adverse effects such as constipation, nausea and pancreatitis. Eluxadoline is also associated with sphincter of Oddi spasm.
How serious is the interaction between Eluxadoline and Paclitaxel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce eluxadoline to 75 mg twice daily if given with OATP1B1 inhibitors, and monitor for abdominal pain, constipation and pancreatitis symptoms.
What other medicines interact with Paclitaxel?
MediHelp also lists interactions of Paclitaxel with, for example, Adenovirus types 4 and 7 live, Cobicistat, Cyclosporine. The full list is on the Paclitaxel page.
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