Drug interactions
Eluxadoline + Quinidine
Severity: Moderate
Eluxadoline and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine strongly inhibits CYP2D6, and the metabolism of eluxadoline is incompletely characterized, so eluxadoline exposure could rise. Eluxadoline may also modestly affect CYP3A4 substrates such as quinidine. Clinical consequences are uncertain but could include more opioid-related and gastrointestinal adverse effects.
What this interaction means in plain words
Eluxadoline and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine inhibits CYP2D6 and may raise eluxadoline levels, while eluxadoline may weakly alter CYP3A4-mediated quinidine metabolism.
What to do
Monitor for eluxadoline adverse effects such as constipation, nausea, abdominal pain and pancreatitis symptoms. Check quinidine levels or ECG if clinical signs of toxicity occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Quinidine?
MediHelp rates the interaction as moderate. Eluxadoline and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine strongly inhibits CYP2D6, and the metabolism of eluxadoline is incompletely characterized, so eluxadoline exposure could rise. Eluxadoline may also modestly affect CYP3A4 substrates such as quinidine. Clinical consequences are uncertain but could include more opioid-related and gastrointestinal adverse effects.
How serious is the interaction between Eluxadoline and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for eluxadoline adverse effects such as constipation, nausea, abdominal pain and pancreatitis symptoms. Check quinidine levels or ECG if clinical signs of toxicity occur.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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