Drug interactions
Eluxadoline + Repaglinide
Severity: Moderate
Eluxadoline and Repaglinide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Repaglinide is an OATP1B1 inhibitor and may raise eluxadoline exposure, increasing its adverse effects such as constipation, nausea and pancreatitis risk. Eluxadoline labeling recommends a reduced dose with OATP1B1 inhibitors.
What this interaction means in plain words
Eluxadoline and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eluxadoline belongs to Gastrointestinal Tract; Repaglinide belongs to Endocrine.
Why it happens
Repaglinide inhibits OATP1B1-mediated hepatic uptake of eluxadoline.
What to do
Reduce eluxadoline to 75 mg twice daily during coadministration and monitor for gastrointestinal and pancreatic adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Repaglinide
- Gemfibrozil + Repaglinide Contraindicated
- Clarithromycin + Repaglinide Major
- Clopidogrel + Repaglinide Major
- Cobicistat + Repaglinide Major
- Cyclosporine + Repaglinide Major
- Cyclosporin + Repaglinide Major
Other interactions of Eluxadoline
Frequently asked questions
Can I take Eluxadoline with Repaglinide?
MediHelp rates the interaction as moderate. Eluxadoline and Repaglinide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Repaglinide is an OATP1B1 inhibitor and may raise eluxadoline exposure, increasing its adverse effects such as constipation, nausea and pancreatitis risk. Eluxadoline labeling recommends a reduced dose with OATP1B1 inhibitors.
How serious is the interaction between Eluxadoline and Repaglinide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reduce eluxadoline to 75 mg twice daily during coadministration and monitor for gastrointestinal and pancreatic adverse effects.
What other medicines interact with Repaglinide?
MediHelp also lists interactions of Repaglinide with, for example, Gemfibrozil, Clarithromycin, Clopidogrel. The full list is on the Repaglinide page.
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